Carbon monoxide and nitric oxide diffusion capacity of formerly exposed asbestos workers with high-resolution computed tomography in a cross-sectional study. in Scientific reports / Sci Rep. 2025 May 2;15(1):15380. doi: 10.1038/s41598-025-99824-w.

2025

Tipo pubblicazione

Journal Article;

Autori/Collaboratori (8)Vedi tutti...

Kraus T
Epidemiology, Biostatistics and Prevention Institute (EBPI), Division of Occupational and Environmental Medicine, University of Zurich, Zurich, Switzerland.
Dressel H
Department of Internal Medicine, Division of Occupational and Environmental Medicine, University Hospital Zurich, Zurich, Switzerland.
Radtke T
Epidemiology, Biostatistics and Prevention Institute (EBPI), Division of Occupational and Environmental Medicine, University of Zurich, Zurich, Switzerland.

et alii...

Abstract

Asbestos exposure can induce pulmonary fibrosis known as asbestosis, and pleural thickening, as well as various cancers. Although lung diffusion capacity (DL) including nitric oxide (NO) is assumed to be more sensitive than carbon monoxide (CO), its added value in assessment of pneumoconiosis has not been investigated yet. 371 formerly exposed workers visiting the outpatient clinic for assessment including pulmonary function testing with DL and low-dose high resolution computed tomography between 2018 and 2021 were included. Subgroups were formed depending on findings in low-dose high resolution computed tomography classified according to ICOERD. Receiver operating characteristic curve (ROC) analysis revealed some diagnostic accuracy for DLNO (AUC = 0.73; 95% confidence interval 0.64-0.82) and DLCO (AUC = 0.70; 95% confidence interval 0.60-0.79) regarding asbestosis, but not per unit alveolar volume. DLCO and DLNO correlated strongly with a decreasing score of irregular opacities according to ICOERD (ρ(DLCO) = - 0.87, ρ(DLNO) = - 0.85) but DLNO was also susceptible to emphysema

PMID : 40316723

DOI : 10.1038/s41598-025-99824-w

Keywords

Humans; Carbon Monoxide/metabolism; Nitric Oxide/metabolism; Male; Cross-Sectional Studies; Middle Aged; Occupational Exposure/adverse effects; Tomography, X-Ray Computed/methods; Female; Asbestos/adverse effects; Aged; Pulmonary Diffusing Capacity; Asbestosis/diagnostic imaging/metabolism/diagnosis; ROC Curve; Respiratory Function Tests; Lung/diagnostic imaging; Adult;